HKPMDC
 All     Test   
 
Pharmacogenomics
Others


Test Name: UGT1A1 Genotyping for Irinotecan Toxicity
Compliance:LDT
Test Description:UGT1A1 gene mutations cause accumulation of toxic metabolite SN-38 (active toxic metabolite of Irinotecan), which may lead to irinotecan-related toxicities (neutropenia, diarrhea). Variations in TA repeat number in the TATAAA element of the 5' UGT1A1-promoter affect transcription efficiency. Individuals homozygous for the A(TA)7TAA allele are at an elevated risk of developing toxicity phenotypes with irinotecan treatment.
Methodology:PCR-Sanger sequencing analysis of promoter region and exon 1 of UGT1A1 gene
Gene Name:

UGT1A1
Protein Name:
Specimen Requirements:EDTA Blood (5mL)
Storage Condition:Ambient Temperature / 4℃ (if overnight is needed)
Turn Around Time:5 working days from day of specimen received
OMIM:
Genetic Home Reference:
Phone: +852.2986.1213
Fax:+852.2527.7028
E-mail:contact@hk-mpdc.com
27/F., Strand 50, No.50 Bonham Strand, Sheung Wan, Hong Kong
Opening Hours
Mondays to Fridays: 09:00-18:00
Saturdays: 09:00-16:00
Sundays and Public Holidays: Closed

For specimen pickup arrangements, please phone +852.2986.1213


Shipping & Billing Information

HOKLAS accreditation scope

Non-disclosure and Complaints
All data/information generated from within/related to HKMPDC and our customers are treated in strict confidence in accordance with the Personal Data (Privacy) Ordinance of Hong Kong. If you have a complaint, please contact us at the (852) 2986 1213 or email us at contact@hk-mpdc.com. All communications with HKMPDC would be dealt with in strict confidence.

Notice of Privacy Practices
This notice describes how medical information about you may be used and disclosed.
Personal health information or related information released to HKMPDC relating to the services requested may be subjected to re-disclosure by HKMPDC to health care providers, such as doctors, nurses, and others involved in the delivery of the services.
We may also disclose medical information about you to authorised public health or government officials for public health activities as required by law and accreditation body.

Copyright © 2013 香港分子病理檢驗中心 Hong Kong Molecular Pathology Diagnostic Centre Limited (HKMPDC). All Rights Reserved.

Information Updated 1 July, 2023.